@article{4d290dc9d5ac49409558d2d265efe0fb,
title = "Brugada syndrome and reduced right ventricular outflow tract conduction reserve: A final common pathway?",
abstract = "Brugada syndrome (BrS) was first described as a primary electrical disorder predisposing to the risk of sudden cardiac death and characterized by right precordial lead ST elevation. Early description of right ventricular structural abnormalities and of right ventricular outflow tract (RVOT) conduction delay in BrS patients set the stage for the current controversy over the pathophysiology underlying the syndrome: channelopathy or cardiomyopathy; repolarization or depolarization. This review examines the current understanding of the BrS substrate, its genetic and non-genetic basis, theories of pathophysiology, and the clinical implications thereof. We propose that the final common pathway for BrS could be viewed as a disease of 'reduced RVOT conduction reserve'. ",
keywords = "Brugada syndrome, Depolarization, Genetics, Right ventricular outflow tract",
author = "Behr, {Elijah R.} and Yael Ben-Haim and Ackerman, {Michael J.} and Krahn, {Andrew D.} and Wilde, {Arthur A.M.}",
note = "Funding Information: We acknowledge support from the Robert Lancaster Memorial Fund, the Netherlands CardioVascular Research Initiative : the Dutch Heart Foundation, Dutch Federation of University Medical Centres, the Netherlands Organisation for Health Research and Development, and the Royal Netherlands Academy of Sciences (PREDICT2). M.J.A. was supported by the Mayo Clinic Windland Smith Rice Comprehensive Sudden Cardiac Death Program. A.D.K. receives support from the Sauder Family and Heart and Stroke Foundation Chair in Cardiology (Vancouver, BC), the Paul Brunes Chair in Heart Rhythm Disorders (Vancouver, BC), and the Paul Albrechtsen Foundation (Winnipeg, MB). Publisher Copyright: {\textcopyright} 2021 Published on behalf of the European Society of Cardiology. All rights reserved. ",
year = "2021",
month = mar,
day = "14",
doi = "10.1093/eurheartj/ehaa1051",
language = "English (US)",
volume = "42",
pages = "1073--1081",
journal = "European heart journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "11",
}