Brugada syndrome and its relevance in the perioperative period

Dan Sorajja, Harish Ramakrishna, A. Poterack, Win Kuang Shen, Farouk Mookadam

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Brugada syndrome is an autosomal dominant genetic disorder associated with an increased risk of sudden cardiac death, as well as ventricular tachyarrhythmias.The defective cardiac sodium channels result in usual electrocardiographic findings of a coved-type ST elevation in precordial leads V1 to V3. The majority of patients have uncomplicated courses with anesthesia, surgery, and invasive procedures. However there is risk of worsening ST elevation and ventricular arrhythmias due to perioperative medications, surgical insult, electrolyte abnormalities, fever, autonomic nervous system tone, as well as other perturbations. Given the increasing numbers of patients with inherited conduction disorders presenting for non-cardiac surgery that are at risk of sudden cardiac death, safe anesthetic management depends upon a detailed knowledge of these conditions.

Original languageEnglish (US)
Pages (from-to)403-413
Number of pages11
JournalAnnals of cardiac anaesthesia
Issue number3
StatePublished - Jul 1 2015


  • Anesthesia
  • Arrhythmias
  • Brugada syndrome
  • Perioperative

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine


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