Breast cancer—The catalyst of contemporary trials design

Zahraa Al-Hilli, Anna Weiss, Ava Armani, Judy C. Boughey, Sarah L. Blair

Research output: Contribution to journalReview articlepeer-review


Surgical trials in breast cancer have catalyzed contemporary trial design for solid organ cancers and are a prime example of surgeons taking the lead in clinical trial design. Surgeons have lead trials that have improved patient outcomes and quality of life without sacrificing oncologic safety. We have evolved from radical mastectomy to breast conservation and sentinel node biopsy. Contemporary trial design in breast cancer now focus on personalizing care based on tumor genomics.

Original languageEnglish (US)
Pages (from-to)7-16
Number of pages10
JournalJournal of Surgical Oncology
Issue number1
StatePublished - Jan 2022


  • breast conservation trials
  • breast surgery clinical trials
  • breast surgery de-escalation

ASJC Scopus subject areas

  • Surgery
  • Oncology


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