Breast Cancer Survivorship Care Variations Between Adjuvant Chemotherapy Regimens

Alexis D. Leal, Holly Van Houten, Lindsey Sangaralingham, Rachel A. Freedman, Ahmedin Jemal, Heather B. Neuman, Tufia C. Haddad, Robert W. Mutter, Theresa H.M. Keegan, Sarah S. Mougalian, Charles L. Loprinzi, Cary P. Gross, Nilay Shah, Kathryn J. Ruddy

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Administrative claims data from a commercial insurance database were analyzed to evaluate differences in rates of outpatient office visits during the year after completion of 4 chemotherapy regimens for early stage breast cancer. Combined anthracycline/taxane was associated with more frequent office visits than docetaxel-cyclophosphamide or doxorubicin-cyclophosphamide, possibly because of greater long-term toxicities. Primary care visits were infrequent. Background: Treatment-related toxicity can vary substantially between chemotherapy regimens. In this study we evaluated the frequency of outpatient office visits among a cohort of early stage breast cancer survivors after completion of 4 different adjuvant chemotherapy regimens to better understand how differences in toxicities between regimens might affect health care use. Materials and Methods: We analyzed administrative claims data from a US commercial insurance database (OptumLabs) to identify women who received adjuvant doxorubicin/cyclophosphamide (AC), AC followed or preceded by docetaxel or paclitaxel (AC-T), AC concurrent with docetaxel or paclitaxel (TAC), or docetaxel/cyclophosphamide (TC) between 2008 and 2014. We compared mean numbers of visits per patient (adjusted for age, race/ethnicity, region, year, surgery type, radiation, chronic conditions, and previous hospitalizations) across the different regimens (TC = reference) for 12 months, starting 4 months after the end of chemotherapy. Results: In 6247 eligible patients, the mean adjusted number of outpatient visits per patient was significantly higher in patients who received AC-T (8.1) or TAC (7.3) than TC (6.5) or AC (6.0; P <.001 for comparisons of AC-T and TAC with TC), primarily because of differences in Medical Oncology visits. Approximately 40% did not see a primary care provider at all during this time frame. Conclusions: AC-T and TAC are associated with more subsequent outpatient visits than TC. Visits to primary care providers are infrequent during the year after completion of chemotherapy.

Original languageEnglish (US)
Pages (from-to)e513-e520
JournalClinical breast cancer
Issue number4
StatePublished - Aug 2018


  • Breast neoplasms
  • Follow-up
  • Health care use
  • Outpatient
  • Toxicity

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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