Boron Neutron Capture Therapy: A Review of Clinical Applications

Timothy D. Malouff, Danushka S. Seneviratne, Daniel K. Ebner, William C. Stross, Mark R. Waddle, Daniel M. Trifiletti, Sunil Krishnan

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Boron neutron capture therapy (BNCT) is an emerging treatment modality aimed at improving the therapeutic ratio for traditionally difficult to treat tumors. BNCT utilizes boronated agents to preferentially deliver boron-10 to tumors, which, after undergoing irradiation with neutrons, yields litihium-7 and an alpha particle. The alpha particle has a short range, therefore preferentially affecting tumor tissues while sparing more distal normal tissues. To date, BNCT has been studied clinically in a variety of disease sites, including glioblastoma multiforme, meningioma, head and neck cancers, lung cancers, breast cancers, hepatocellular carcinoma, sarcomas, cutaneous malignancies, extramammary Paget’s disease, recurrent cancers, pediatric cancers, and metastatic disease. We aim to provide an up-to-date and comprehensive review of the studies of each of these disease sites, as well as a review on the challenges facing adoption of BNCT.

Original languageEnglish (US)
Article number601820
JournalFrontiers in Oncology
StatePublished - Feb 26 2021


  • boron neutron capture
  • boron neutron capture therapy (BNCT)
  • fast neutrons
  • particles
  • radiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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