Boron Neutron Capture Therapy

Danushka Seneviratne, Timothy Malouff, Deanna Pafundi, Daniel Trifiletti, Sunil Krishnan

Research output: Chapter in Book/Report/Conference proceedingChapter


Boron neutron capture theory (BNCT) is an innovative method of treating tumors by selectively irradiating cancer cells that have accumulated boron compounds. Given that BNCT is an uncommon treatment modality, there are no widely accepted consensus guidelines regarding beam dosimetry. To date, BNCT has been studied clinically in several disease sites, including GBM, meningioma, head and neck cancers, lung cancers, breast cancers, hepatocellular carcinoma, sarcomas, cutaneous malignancies, extra-mammary Paget's disease, recurrent cancers, pediatric cancers, and metastatic disease. The chapter provides a comprehensive review of the clinical studies for each of these disease sites, as well as a review on the challenges limiting the widespread adoption of BNCT. In a similar study of biodistribution and pharmacokinetics of boron in dogs following administration of boronated porphyrin (BOPP), boron was found to primarily accumulate in the liver, lymph nodes, adrenal, and kidney tissues with very low level accumulation in the brain.

Original languageEnglish (US)
Title of host publicationPrinciples and Practice of Particle Therapy
Number of pages15
ISBN (Electronic)9781119707530
ISBN (Print)9781119707516
StatePublished - Jan 1 2022


  • Beam dosimetry
  • Boron neutron capture theory
  • Boronated porphyrin
  • Clinical studies
  • Pharmacokinetics

ASJC Scopus subject areas

  • General Medicine


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