Bisphosphonate-associated femoral fracture: Implications for management

Nicola Napoli, Ilenia Pepe, Reinaarmamento-Villareal, Antonino Agrusa, Maria Ritarinella, Francesca Scozzari, Florianaadragna, Edy Costanzagaglio, Gaspare Cusumano, Umberto Martorana, Gasparegulotta, Valentina Cannone

Research output: Contribution to journalArticlepeer-review


Studies carried out on individuals being treated long term with bisphosphonates have provoked considerable interest and perplexity about the effect that these drugs have on bone turnover in the long run. In fact the experiences reported by numerous researchers tend to highlight how treatment with high doses of bisphosphonates over many years, of individuals with osteoporosis complicated by or secondary to neoplastic pathologies, causes a suppression of bone turnover that over time predisposes the bone to the accumulation of micro damage that can then result in complicated fractures, as in the case described here.

Original languageEnglish (US)
Pages (from-to)131-132
Number of pages2
JournalActa Medica Mediterranea
Issue number3
StatePublished - 2008


  • Bisphonates
  • Bone turnover
  • Femoral fractures

ASJC Scopus subject areas

  • General Medicine


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