Biomedical spectral x-ray imaging; Promises and challenges

Steven M. Jorgensen, Diane R. Eaker, Erik L. Ritman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations


Imaging arrays with sub-millimeter detector pixels that count and allocate energy to each detected photon are now being introduced into biomedical computed tomography scanners. Consequently, bremsstrahlung x-ray can provide the advantages of simultaneous recording of multiple quasi-monochromatic x-ray images which can be used for identification of various materials within the image field. This capability increases the inherent contrast within biomedical CT images and also introduces the ability to use high atomic weight "foreign" elements (e.g., strontium) which are surrogates for "native" biological elements (e.g., calcium) to monitor tissue function (e.g., bone deposition). Challenges for this methodology include limited maximum fluence due to photon pile-up, charge-sharing between contiguous pixels and heterogeneous pixel characteristics due to manufacturing difficulties.

Original languageEnglish (US)
Title of host publicationAdvances in X-Ray/EUV Optics and Components VI
StatePublished - 2011
EventAdvances in X-Ray/EUV Optics and Components VI - San Diego, CA, United States
Duration: Aug 22 2011Aug 24 2011

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


OtherAdvances in X-Ray/EUV Optics and Components VI
Country/TerritoryUnited States
CitySan Diego, CA


  • Beam hardening
  • Charge sharing
  • Clinical CT
  • Dual-energy X-ray
  • Kedge
  • Micro-CT
  • Photon counting
  • Photon pile-up
  • X-ray Scatter
  • X-ray fluorescence

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


Dive into the research topics of 'Biomedical spectral x-ray imaging; Promises and challenges'. Together they form a unique fingerprint.

Cite this