Biomarkers for prognosis in pancreatic neuroendocrine tumors

Mojun Zhu, Karl R. Sorenson, Rebecca Liu, Bonnie E. Gould Rothberg, Thorvardur R. Halfdanarson

Research output: Contribution to journalArticlepeer-review


Pancreatic neuroendocrine tumors (PNETs) encompass a diverse group of malignancies marked by histological heterogeneity and highly variable clinical outcomes. We performed a systematic review on potential prognostic biomarkers in PNETs by searching the PubMed database. A total of 472 manuscripts were reviewed in detail, of which 52 multivariate studies met the inclusion criteria proposed by the Reporting Recommendations for Tumor Marker Prognostic Studies. These altogether analyzed 53 unique targets, and 36 of them were statistically associated with survival.

Original languageEnglish (US)
Pages (from-to)773-782
Number of pages10
JournalEndocrine-Related Cancer
Issue number12
StatePublished - Dec 2021


  • biomarker
  • neuroendocrine
  • pancreatic
  • prognosis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Oncology
  • Endocrinology
  • Cancer Research


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