Biological challenges of phage therapy and proposed solutions: a literature review

Katherine M. Caflisch; Gina A. Suh; Robin Patel

doi:10.1080/14787210.2019.1694905

Biological challenges of phage therapy and proposed solutions: a literature review

Katherine M. Caflisch, Gina A. Suh, Robin Patel

Laboratory Medicine and Pathology

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Introduction: In light of the emergence of antibiotic-resistant bacteria, phage (bacteriophage) therapy has been recognized as a potential alternative or addition to antibiotics in Western medicine for use in humans. Areas covered: This review assessed the scientific literature on phage therapy published between 1 January 2007 and 21 October 2019, with a focus on the successes and challenges of this prospective therapeutic. Expert opinion: Efficacy has been shown in animal models and experimental findings suggest promise for the safety of human phagotherapy. Significant challenges remain to be addressed prior to the standardization of phage therapy in the West, including the development of phage-resistant bacteria; the pharmacokinetic complexities of phage; and any potential human immune response incited by phagotherapy.

Original language	English (US)
Pages (from-to)	1011-1041
Number of pages	31
Journal	Expert Review of Anti-Infective Therapy
Volume	17
Issue number	12
DOIs	https://doi.org/10.1080/14787210.2019.1694905
State	Published - Dec 2 2019

Keywords

Phage
endolysin
phage resistance
phage therapy
phagotherapy

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Virology
Infectious Diseases

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10.1080/14787210.2019.1694905

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title = "Biological challenges of phage therapy and proposed solutions: a literature review",

abstract = "Introduction: In light of the emergence of antibiotic-resistant bacteria, phage (bacteriophage) therapy has been recognized as a potential alternative or addition to antibiotics in Western medicine for use in humans. Areas covered: This review assessed the scientific literature on phage therapy published between 1 January 2007 and 21 October 2019, with a focus on the successes and challenges of this prospective therapeutic. Expert opinion: Efficacy has been shown in animal models and experimental findings suggest promise for the safety of human phagotherapy. Significant challenges remain to be addressed prior to the standardization of phage therapy in the West, including the development of phage-resistant bacteria; the pharmacokinetic complexities of phage; and any potential human immune response incited by phagotherapy.",

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Biological challenges of phage therapy and proposed solutions: a literature review

Abstract

Keywords

ASJC Scopus subject areas

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