Biologic activity of rhBMP-2 following release from PLGA microspheres

Jacob B. Oldham; Blaise D. Porter; Theresa E. Hefferan; Bradford L. Currier; Antonios G. Mikos; Michael J. Yaszemski

Biologic activity of rhBMP-2 following release from PLGA microspheres

Jacob B. Oldham, Blaise D. Porter, Theresa E. Hefferan, Bradford L. Currier, Antonios G. Mikos, Michael J. Yaszemski

Orthopedic Surgery

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The encapsulation of rhBMP-2 in polymeric microspheres, as well as its biologic activity upon release were investigated. It was observed that rhBMP-2 can be encapsulated in poly(lactic/glycolic acid) (PLGA) microspheres and that the protein remains active after release from the microspheres.

Original language	English (US)
Title of host publication	American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Publisher	ASME
Pages	745-746
Number of pages	2
Volume	42
ISBN (Print)	0791816117
State	Published - Dec 1 1999
Event	1999 Bioengineering Conference - Big Sky, MT, USA Duration: Jun 16 1999 → Jun 20 1999

Other

Other	1999 Bioengineering Conference
City	Big Sky, MT, USA
Period	6/16/99 → 6/20/99

ASJC Scopus subject areas

Engineering(all)

Cite this

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title = "Biologic activity of rhBMP-2 following release from PLGA microspheres",

abstract = "The encapsulation of rhBMP-2 in polymeric microspheres, as well as its biologic activity upon release were investigated. It was observed that rhBMP-2 can be encapsulated in poly(lactic/glycolic acid) (PLGA) microspheres and that the protein remains active after release from the microspheres.",

author = "Oldham, {Jacob B.} and Porter, {Blaise D.} and Hefferan, {Theresa E.} and Currier, {Bradford L.} and Mikos, {Antonios G.} and Yaszemski, {Michael J.}",

year = "1999",

month = dec,

day = "1",

language = "English (US)",

isbn = "0791816117",

volume = "42",

pages = "745--746",

booktitle = "American Society of Mechanical Engineers, Bioengineering Division (Publication) BED",

publisher = "ASME",

note = "1999 Bioengineering Conference ; Conference date: 16-06-1999 Through 20-06-1999",

}

TY - GEN

T1 - Biologic activity of rhBMP-2 following release from PLGA microspheres

AU - Oldham, Jacob B.

AU - Porter, Blaise D.

AU - Hefferan, Theresa E.

AU - Currier, Bradford L.

AU - Mikos, Antonios G.

AU - Yaszemski, Michael J.

PY - 1999/12/1

Y1 - 1999/12/1

N2 - The encapsulation of rhBMP-2 in polymeric microspheres, as well as its biologic activity upon release were investigated. It was observed that rhBMP-2 can be encapsulated in poly(lactic/glycolic acid) (PLGA) microspheres and that the protein remains active after release from the microspheres.

AB - The encapsulation of rhBMP-2 in polymeric microspheres, as well as its biologic activity upon release were investigated. It was observed that rhBMP-2 can be encapsulated in poly(lactic/glycolic acid) (PLGA) microspheres and that the protein remains active after release from the microspheres.

UR - http://www.scopus.com/inward/record.url?scp=0033297170&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033297170&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:0033297170

SN - 0791816117

VL - 42

SP - 745

EP - 746

BT - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

PB - ASME

T2 - 1999 Bioengineering Conference

Y2 - 16 June 1999 through 20 June 1999

ER -

Biologic activity of rhBMP-2 following release from PLGA microspheres

Abstract

Other

ASJC Scopus subject areas

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