Big gulps: specialized membrane domains for rapid receptor-mediated endocytosis

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Eukaryotic cells are well known to use an elaborate, clathrin-based endocytic machinery to internalize ligand-receptor complexes. Although the number of components identified as being used during this essential process has increased substantially over the past decade, an appreciation for how receptor-mediated endocytosis is organized at a broader, cellular scale is still mostly undefined. Here, some new insights into how cells cluster and organize the endocytic machinery at defined cytoplasmic domains to increase the speed and efficiency of ligand-receptor internalization are presented.

Original languageEnglish (US)
Pages (from-to)487-492
Number of pages6
JournalTrends in Cell Biology
Issue number10
StatePublished - Oct 2006

ASJC Scopus subject areas

  • Cell Biology


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