Beneficial effects of low doses of red wine consumption on perturbed shear stress-induced atherogenesis

Claudio Napoli, Maria Luisa Balestrieri, Vincenzo Sica, Lilach O. Lerman, Ettore Crimi, Gaetano De Rosa, Concetta Schiano, Luigi Servillo, Francesco P. D'Armiento

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Moderate wine intake is associated with a reduced risk of morbidity and mortality from cardiovascular disease. Atherosclerosis is enhanced in arterial segments exposed to disturbed flow. Perturbed shear stress increases also the endothelial expression of oxidation-sensitive responsive genes (such as ELK-1 and p-JUN). This study evaluates the effects of chronic consumption of red wine on perturbed shear stress-induced atherogenesis. Results indicated that chronic treatment with red wine significantly attenuated the activation of redox-sensitive genes (ELK-1 and p-JUN) and increased endothelial nitric oxide synthase (eNOS) expression (which was decreased by perturbed shear stress) in cultured human coronary endothelial cells (EC) and in atherosclerosis-prone areas of hypercholesterolemic mice. Oral administration of red wine to hypercholesterolemic mice reduced significantly the progression of atherosclerosis. Moreover, short-term supplementation with red wine to C57BL/6J mice significantly increased upregulation of aortic eNOS and SIRT1 expression induced by physical training. These findings establish that administration of low doses of red wine can attenuate the proatherogenic effects induced by perturbed shear stress in vitro and in vivo. This evidence may have implications for the prevention of atherosclerotic lesion progression and its clinical manifestations.

Original languageEnglish (US)
Pages (from-to)124-133
Number of pages10
JournalHeart and vessels
Issue number2
StatePublished - Mar 2008


  • Antioxidant
  • Endothelial progenitor cell
  • Polyphenol
  • Red wine
  • Shear stress

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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