Autonomic function in hereditary motor and sensory neuropathy (charcot‐marie‐tooth disease)

Timothy J. Ingall, James G. McLeod

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Autonomic tests of heart rate and blood pressure control using both invasive and noninvasive techniques were performed on 11 patients with hereditary motor and sensory neuropathy (HMSN) types 1, and 4 patients with HMSN type 2. The results were compared with those of 76 control subjects. No significant difference was found between the patient and control groups. Impairment of sweating on the extremities was found in patients with HMSN types 1 and 2, consistent with distal degeneration of sympathetic fibers in peripheral nerves, but there were no abnormalities of cardiovascular reflex control mechanisms.

Original languageEnglish (US)
Pages (from-to)1080-1083
Number of pages4
JournalMuscle & Nerve
Issue number11
StatePublished - Nov 1991


  • Charcot‐Marie‐Tooth disease
  • autonomic function
  • cardiovascular reflexes
  • hereditary motor and sensory neuropathy
  • sweat test

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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