Automated evaluation of respiratory signals to provide insight into respiratory drive

Obaid U. Khurram, Heather M. Gransee, Gary C. Sieck, Carlos B. Mantilla

Research output: Contribution to journalArticlepeer-review


The diaphragm muscle (DIAm) is the primary inspiratory muscle in mammals and is highly active throughout life displaying rhythmic activity. The repetitive activation of the DIAm (and of other muscles driven by central pattern generator activity) presents an opportunity to analyze these physiological data on a per-event basis rather than pooled on a per-subject basis. The present study highlights the development and implementation of a graphical user interface-based algorithm using an analysis of critical points to detect the onsets and offsets of individual respiratory events across a range of motor behaviors, thus facilitating analyses of within-subject variability. The algorithm is designed to be robust regardless of the signal type (e.g., EMG or transdiaphragmatic pressure). Our findings suggest that this approach may be particularly beneficial in reducing animal numbers in certain types of studies, for assessments of perturbation studies where the effects are relatively small but potentially physiologically meaningful, and for analyses of respiratory variability.

Original languageEnglish (US)
Article number103872
JournalRespiratory Physiology and Neurobiology
StatePublished - Jun 2022


  • Diaphragm muscle
  • Motor control
  • Motor unit
  • Respiratory
  • Statistics
  • Variability

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Automated evaluation of respiratory signals to provide insight into respiratory drive'. Together they form a unique fingerprint.

Cite this