Autoimmune myelopathy associated with collapsin response-mediator protein-5 immunoglobulin G

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47 Scopus citations


Several autoimmune myelopathies are recognized clinically. We describe 57 patients in whom serological evaluation for myelopathy of uncertain cause demonstrated collapsin response-mediator protein-5 IgG. Most had spinal imaging and cerebrospinal fluid abnormalities and insidiously progressive presentation; some had acute monophasic or relapsing myelopathy. Initial diagnoses included multiple sclerosis, transverse myelitis, and unspecified neurodegenerative myelopathy. Most were smokers; neoplasia was discovered in 68% (most commonly small-cell lung carcinoma and after collapsin response-mediator protein-5 IgG detection). Collapsin response-mediator protein-5 autoimmune myelopathy and occult neoplasia are important considerations in patients with insidiously progressive myelopathy, especially with known cancer risk.

Original languageEnglish (US)
Pages (from-to)531-534
Number of pages4
JournalAnnals of neurology
Issue number4
StatePublished - Apr 2008

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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