Atrial fibrillation, cognitive impairment, and neuroimaging

Jonathan Graff-Radford, Malini Madhavan, Prashanthi Vemuri, Alejandro A. Rabinstein, Ruth H. Cha, Michelle M. Mielke, Kejal Kantarci, Val Lowe, Matthew L. Senjem, Jeffrey L. Gunter, David S. Knopman, Ronald C. Petersen, Clifford R. Jack, Rosebud O. Roberts

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Introduction The objective of our study was to investigate cross-sectional associations of atrial fibrillation with neuroimaging measures of cerebrovascular disease and Alzheimer's disease and their interactions with mild cognitive impairment (MCI). Methods Magnetic resonance imaging scans of individuals from a population-based study were analyzed for infarctions, total gray matter, and hippocampal and white matter hyperintensity volumes. A subsample underwent positron emission tomography imaging. Results Atrial fibrillation was associated with infarctions and lower total gray matter volume. Compared with subjects with no atrial fibrillation and no infarction, the odds ratio (95% confidence intervals) for MCI was 2.99 (1.57-5.70; P =.001) among participants with atrial fibrillation and infarction, 0.90 (0.45-1.80; P =.77) for atrial fibrillation and no infarction, and 1.50 (0.96-2.34; P =.08) for no atrial fibrillation and any infarction. Discussion Participants with both atrial fibrillation and infarction are more likely to have MCI than participants with either infarction or atrial fibrillation alone.

Original languageEnglish (US)
Pages (from-to)391-398
Number of pages8
JournalAlzheimer's and Dementia
Issue number4
StatePublished - Apr 1 2016


  • Alzheimer's disease
  • Atrial fibrillation
  • Cerebrovascular disease
  • Mild cognitive impairment
  • Stroke

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health


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