Asymptomatic lambert-eaton syndrome

Eric H. Denys, Vanda A. Lennon

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Introduction: All descriptions of the Lambert-Eaton syndrome are based on symptomatic patients. We incidentally encountered electromyographic evidence of this syndrome in a patient being studied for another reason. The patient had controlled hypothyroidism and smoked for 9 pack-years but never had symptoms of weakness or had evidence of cancer. Methods: Detailed electrophysiological and serological evaluations were undertaken in this study. Results: Neuromuscular transmission tests were consistent with a presynaptic disorder. Autoantibodies specific for P/Q-type voltage-gated calcium channels (VGCC) were detected in the serum and persisted throughout 7 years of follow-up. Multiple IgG markers of thyrogastric autoimmunity also were detected. Conclusions: This demonstration of asymptomatic Lambert-Eaton syndrome persisting for 8 years provided novel insight into the natural history of the disorder. It is plausible that patients with a subclinical syndrome would have abrupt neuromuscular decompensation when challenged with medications that compromise the safety factor for synaptic transmission.

Original languageEnglish (US)
Pages (from-to)764-767
Number of pages4
JournalMuscle and Nerve
Issue number5
StatePublished - May 2014


  • Lambert-Eaton syndrome
  • Myasthenic syndrome
  • Organ-specific autoimmunity
  • Pernicious anemia
  • Voltage-gated calcium channels

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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