Asthma and the risk of rheumatoid arthritis: An insight into the heterogeneity and phenotypes of asthma

Mary Claire Rolfes, Young Jun Juhn, S. I. Wi, Youn Ho Sheen

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Asthma is traditionally regarded as a chronic airway disease, and recent literature proves its heterogeneity, based on distinctive clusters or phenotypes of asthma. In defining such asthma clusters, the nature of comorbidity among patients with asthma is poorly understood, by assuming no causal relationship between asthma and other comorbid conditions, including both communicable and non communicable diseases. However, emerging evidence suggests that the status of asthma significantly affects the increased susceptibility of the patient to both communicable and noncommunicable diseases. Specifically, the impact of asthma on susceptibility to non communicable diseases such as chronic systemic inflammatory diseases (e.g., rheumatoid arthritis), may provide an important insight into asthma as a disease with systemic inflammatory features, a conceptual understanding between asthma and asthma-related comorbidity, and the potential implications on the therapeutic and preventive interventions for patients with asthma. This review discusses the currently under-recognized clinical and immunological phenotypes of asthma; specifically, a higher risk of developing a systemic inflammatory disease such as rheumatoid arthritis and their implications, on the conceptual understanding and management of asthma. Our discussion is divided into three parts: literature summary on the relationship between asthma and the risk of rheumatoid arthritis; potential mechanisms underlying the association; and implications on asthma management and research.

Original languageEnglish (US)
Pages (from-to)113-135
Number of pages23
JournalTuberculosis and Respiratory Diseases
Issue number2
StatePublished - Apr 2017


  • Arthritis, Rheumatoid
  • Asthma
  • Comorbidity
  • Epidemiology
  • Genetic Heterogeneity
  • Phenotype
  • Risk

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases


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