TY - JOUR
T1 - Association of parameters of nocturnal hypoxemia with diabetic microvascular complications
T2 - A cross-sectional study
AU - Xue, Pei
AU - Covassin, Naima
AU - Ran, Xingwu
AU - Zhou, Junying
AU - Zhang, Xiaohan
AU - Yan, Donge
AU - Li, Xiao
AU - Gao, Yun
AU - Tang, Xiangdong
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China ( 81700087 , 81530002 ).
Funding Information:
The authors acknowledge all the physicians at Sleep Medicine Center participating in the collections of patients. This work was supported by the National Natural Science Foundation of China (81700087, 81530002). All authors participated in designing the study. XP and GY completed the analyses and drafted the manuscript. All authors helped to interpret the data, revised the manuscript, provided intellectual content to the work, and gave their final approval to the paper to be published.
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/12
Y1 - 2020/12
N2 - Aims: To examine the association between obstructive sleep apnea (OSA)-related nocturnal hypoxemia parameters and diabetic microvascular complications in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 463 Chinese patients with T2DM underwent overnight polysomnography, followed by diagnosis of diabetic microvascular complications including diabetic peripheral neuropathy (DPN), diabetic retinopathy (DR) and diabetic nephropathy (DN). Parameters of nocturnal hypoxemia, including apnea-hypopnea index (AHI), oxygen desaturation index (ODI), time spent with SpO2 < 90% (T90%) or <85% (T85%), mean SpO2 and lowest SpO2, were recorded. Results: AHI was independently associated with higher odds of DPN (OR 1.19; 95% CI, 1.05–1.36; P = 0.008) after adjustment for possible confounders. Moreover, patients with severe OSA (AHI ≥ 30 events/h) had higher likelihood of having DPN than those with mild OSA (OR 2.36; 95% CI, 1.31–4.25; P = 0.004). When combining DPN, DR and DN into an overall diabetic microvascular complication index, AHI was also independently associated with higher odds of having any diabetic microvascular complication (OR 1.21; 95% CI, 1.06–1.38; P = 0.006). Conclusions: The AHI may be the OSA-related index that most strongly reflects the association of OSA and diabetic microvascular complications, compared with other OSA-related hypoxemia parameters.
AB - Aims: To examine the association between obstructive sleep apnea (OSA)-related nocturnal hypoxemia parameters and diabetic microvascular complications in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 463 Chinese patients with T2DM underwent overnight polysomnography, followed by diagnosis of diabetic microvascular complications including diabetic peripheral neuropathy (DPN), diabetic retinopathy (DR) and diabetic nephropathy (DN). Parameters of nocturnal hypoxemia, including apnea-hypopnea index (AHI), oxygen desaturation index (ODI), time spent with SpO2 < 90% (T90%) or <85% (T85%), mean SpO2 and lowest SpO2, were recorded. Results: AHI was independently associated with higher odds of DPN (OR 1.19; 95% CI, 1.05–1.36; P = 0.008) after adjustment for possible confounders. Moreover, patients with severe OSA (AHI ≥ 30 events/h) had higher likelihood of having DPN than those with mild OSA (OR 2.36; 95% CI, 1.31–4.25; P = 0.004). When combining DPN, DR and DN into an overall diabetic microvascular complication index, AHI was also independently associated with higher odds of having any diabetic microvascular complication (OR 1.21; 95% CI, 1.06–1.38; P = 0.006). Conclusions: The AHI may be the OSA-related index that most strongly reflects the association of OSA and diabetic microvascular complications, compared with other OSA-related hypoxemia parameters.
KW - Diabetic microvascular complications
KW - Nocturnal hypoxemia
KW - Obstructive sleep apnea
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U2 - 10.1016/j.diabres.2020.108484
DO - 10.1016/j.diabres.2020.108484
M3 - Article
C2 - 33031843
AN - SCOPUS:85092937374
SN - 0168-8227
VL - 170
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
M1 - 108484
ER -