@article{4cc490f16e3f44889c5fbc7e165d85de,
title = "Association of a let-7 miRNA binding region of TGFBR1 with hereditary mismatch repair proficient colorectal cancer (MSS HNPCC)",
abstract = "The purpose of this study was to identify novel colorectal cancer (CRC)-causing alleles in unexplained familial CRC cases. In order to do so, coding regions in five candidate genes (MGMT, AXIN2, CTNNB1, TGFBR1 and TGFBR2) were sequenced in 11 unrelated microsatellite-stable hereditary non-polyposis CRC (MSS HNPCC) cases. Selected genetic variants were genotyped in a discovery set of 27 MSS HNPCC cases and 85 controls. One genetic variant, rs67687202, in TGFBR1 emerged as significant (P = 0.002), and it was genotyped in a replication set of 87 additional MSS HNPCC-like cases and 338 controls where it was also significantly associated with MSS HNPCC cases (P = 0.041). In the combined genotype data, rs67687202 was associated with a moderate increase in CRC risk (OR = 1.68; 95% CI = 1.13-2.50; P = 0.010). We tested a highly correlated SNP rs868 in 723 non-familial CRC cases compared with 629 controls, and it was not significantly associated with CRC risk (P = 0.370). rs868 is contained in a let-7 miRNA binding site in the 3'UTR of TGFBR1, which might provide a functional basis for the association.",
author = "Xicola, {Rosa M.} and Sneha Bontu and Doyle, {Brian J.} and Jamie Rawson and Pilar Garre and Esther Lee and {De la Hoya}, Miguel and Xavier Bessa and Joan Clofent and Luis Bujanda and Francesc Balaguer and Sergi Castellv{\'i}-Bel and Cristina Alenda and Rodrigo Jover and Clara Ruiz-Ponte and Sapna Syngal and Montserrat Andreu and Angel Carracedo and Antoni Castells and Newcomb, {Polly A.} and Noralane Lindor and Potter, {John D.} and Baron, {John A.} and Ellis, {Nathan A.} and Trinidad Caldes and Lor, {Xavier L.}",
note = "Funding Information: This work was supported in part by Sirazi Foundation; Area of Excellence Award from the University of Illinois at Chicago, Office of the Vice Chancellor for Research; the Department of Medicine and Cancer Center of the University of Illinois (X.L.). T.C., P.G. and M.d.H. were supported by PI13/02588 and RD12/0036/006 from ISCIII (Spain) and the European Regional Development FEDER funds. The Colon Cancer Family Registry (CCFR) was supported by grant UM1 CA167551 from the National Cancer Institute. The following CCFR centers provided samples and data for this study: Australasian Colorectal Cancer Family Registry (U01/U24 CA097735), USC Consortium Colorectal Cancer Family Registry (U01/U24 CA074799), Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (U01/U24 CA074800), Ontario Registry for Studies of Familial Colorectal Cancer (U01/U24 CA074783), Seattle Colorectal Cancer Family Registry (U01/U24 CA074794) and University of Hawaii Colorectal Cancer Family Registry (U01/U24 CA074806). The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centers in the CCFR, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government or the CCFR. The study sponsors had no role in the design of the study; no role in the collection, analysis or interpretation of the data; no role in the writing of the manuscript and no role in the decision to submit the manuscript for publication. Publisher Copyright: {\textcopyright} The Author's 2016.",
year = "2016",
month = aug,
day = "1",
doi = "10.1093/carcin/bgw064",
language = "English (US)",
volume = "37",
pages = "751--758",
journal = "Carcinogenesis",
issn = "0143-3334",
publisher = "Oxford University Press",
number = "8",
}