TY - JOUR
T1 - Association between atopic dermatitis and squamous cell carcinoma
T2 - a case–control study
AU - Cho, Janice M.
AU - Davis, Dawn Marie R.
AU - Wetter, David A.
AU - Bartley, Adam C.
AU - Brewer, Jerry D.
N1 - Funding Information:
We thank Clint Hagen from the Department of Health Sciences Research, Mayo Clinic, for his expert advice and statistical support.
Publisher Copyright:
© 2017 The International Society of Dermatology
PY - 2018/3
Y1 - 2018/3
N2 - Background: Conflicting data have been published on whether an association exists between atopic dermatitis (AD) and nonmelanoma skin cancer. This study aimed to determine whether individuals with AD had an increased risk of squamous cell carcinoma (SCC) development. Methods: We conducted a retrospective, case–control study of patients residing in Olmsted County, Minnesota. Cases were selected from patients seen at Mayo Clinic (Rochester, Minnesota) who had an initial SCC diagnosis (either invasive SCC or SCC in situ) from January 1, 1996, through December 23, 2010. Age- and sex-matched controls were selected from patients seen at Mayo Clinic with no history of SCC before the case event date. Results: Three hundred ninety-nine individuals with a documented history of SCC were identified and matched with 780 controls who did not have a history of SCC. After adjusting for race, smoking history, ionizing radiation exposure, corticosteroid and cyclosporine use, and non-SCC skin cancers, the odds ratio for SCC development between patients with history of AD versus patients without history of AD was 1.75 (95% CI, 1.05–2.93). Conclusions: Our findings support an increased risk of SCC development in the setting of AD.
AB - Background: Conflicting data have been published on whether an association exists between atopic dermatitis (AD) and nonmelanoma skin cancer. This study aimed to determine whether individuals with AD had an increased risk of squamous cell carcinoma (SCC) development. Methods: We conducted a retrospective, case–control study of patients residing in Olmsted County, Minnesota. Cases were selected from patients seen at Mayo Clinic (Rochester, Minnesota) who had an initial SCC diagnosis (either invasive SCC or SCC in situ) from January 1, 1996, through December 23, 2010. Age- and sex-matched controls were selected from patients seen at Mayo Clinic with no history of SCC before the case event date. Results: Three hundred ninety-nine individuals with a documented history of SCC were identified and matched with 780 controls who did not have a history of SCC. After adjusting for race, smoking history, ionizing radiation exposure, corticosteroid and cyclosporine use, and non-SCC skin cancers, the odds ratio for SCC development between patients with history of AD versus patients without history of AD was 1.75 (95% CI, 1.05–2.93). Conclusions: Our findings support an increased risk of SCC development in the setting of AD.
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U2 - 10.1111/ijd.13857
DO - 10.1111/ijd.13857
M3 - Article
AN - SCOPUS:85038011388
SN - 0011-9059
VL - 57
SP - 313
EP - 316
JO - International journal of dermatology
JF - International journal of dermatology
IS - 3
ER -