Assignment of the Human Gene for the α1 Subunit of the Skeletal Muscle DHP-Sensitive Ca2+ Channel (CACNL1A3) to Chromosome 1q31-q32

Ronald G. Gregg; Fergus Couch; Kirk Hogan; Patricia A. Powers

doi:10.1006/geno.1993.1017

Assignment of the Human Gene for the α₁ Subunit of the Skeletal Muscle DHP-Sensitive Ca²⁺ Channel (CACNL1A3) to Chromosome 1q31-q32

Ronald G. Gregg
, Fergus Couch
, Kirk Hogan
, Patricia A. Powers

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

A human clone corresponding to the gene encoding the α₁ subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (CACNL1A3) has been isolated and partially sequenced. Oligonucleotides based on this sequence were used in a polymerase chain reaction to amplify specifically the human gene in human-rodent somatic cell hybrids, allowing the assignment of CACNL1A3 to chromosome 1. A polymorphic dinucleotide repeat also was identified in the human clone and using PCR was typed on a subset of the CEPH families. Multipoint linkage analysis places the CACNL1A3 gene between D1S52 and D1S70, on chromosome 1q31-q32.

Original language	English (US)
Pages (from-to)	107-112
Number of pages	6
Journal	Genomics
Volume	15
Issue number	1
DOIs	https://doi.org/10.1006/geno.1993.1017
State	Published - Jan 1993

ASJC Scopus subject areas

Genetics

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AU - Hogan, Kirk

AU - Powers, Patricia A.

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AB - A human clone corresponding to the gene encoding the α1 subunit of the skeletal muscle dihydropyridine-sensitive calcium channel (CACNL1A3) has been isolated and partially sequenced. Oligonucleotides based on this sequence were used in a polymerase chain reaction to amplify specifically the human gene in human-rodent somatic cell hybrids, allowing the assignment of CACNL1A3 to chromosome 1. A polymorphic dinucleotide repeat also was identified in the human clone and using PCR was typed on a subset of the CEPH families. Multipoint linkage analysis places the CACNL1A3 gene between D1S52 and D1S70, on chromosome 1q31-q32.

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Assignment of the Human Gene for the α₁ Subunit of the Skeletal Muscle DHP-Sensitive Ca²⁺ Channel (CACNL1A3) to Chromosome 1q31-q32

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