Assessing linkage on chromosome 5 using components of variance approach: Univariate versus multivariate

M. De Andrade; T. J. Thiel; Li Ping Yu; C. I. Amos

doi:10.1002/(SICI)1098-2272(1997)14:6<773::AID-GEPI35>3.0.CO;2-L

Assessing linkage on chromosome 5 using components of variance approach: Univariate versus multivariate

M. De Andrade, T. J. Thiel, Li Ping Yu, C. I. Amos

Quantitative Health Sciences

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31 Scopus citations

Abstract

We report when one disease related quantitative trait (Q1) is analyzed versus multiple related quantitative traits using a components of variance approach [Amos, 1994; de Andrade and Amos, 1996]. In both cases, we used age, sex and environmental factor (EF) as covariates. Analysis with ascertainment correction of samples selected through probands with extremely high trait values was also performed and is presented. Testing procedures to detect linkage using the components of variance approach are discussed. The univariate and multivariate analyses showed effects of locus 15 on chromosome 5 only for Q1. This result was confirmed when using ascertainment correction.

Original language	English (US)
Pages (from-to)	773-778
Number of pages	6
Journal	Genetic epidemiology
Volume	14
Issue number	6
DOIs	https://doi.org/10.1002/(SICI)1098-2272(1997)14:6<773::AID-GEPI35>3.0.CO;2-L
State	Published - 1997

ASJC Scopus subject areas

Epidemiology
Genetics(clinical)

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10.1002/(SICI)1098-2272(1997)14:6<773::AID-GEPI35>3.0.CO;2-L

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abstract = "We report when one disease related quantitative trait (Q1) is analyzed versus multiple related quantitative traits using a components of variance approach [Amos, 1994; de Andrade and Amos, 1996]. In both cases, we used age, sex and environmental factor (EF) as covariates. Analysis with ascertainment correction of samples selected through probands with extremely high trait values was also performed and is presented. Testing procedures to detect linkage using the components of variance approach are discussed. The univariate and multivariate analyses showed effects of locus 15 on chromosome 5 only for Q1. This result was confirmed when using ascertainment correction.",

author = "{De Andrade}, M. and Thiel, {T. J.} and Yu, {Li Ping} and Amos, {C. I.}",

year = "1997",

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T1 - Assessing linkage on chromosome 5 using components of variance approach

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AU - De Andrade, M.

AU - Thiel, T. J.

AU - Yu, Li Ping

AU - Amos, C. I.

PY - 1997

Y1 - 1997

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AB - We report when one disease related quantitative trait (Q1) is analyzed versus multiple related quantitative traits using a components of variance approach [Amos, 1994; de Andrade and Amos, 1996]. In both cases, we used age, sex and environmental factor (EF) as covariates. Analysis with ascertainment correction of samples selected through probands with extremely high trait values was also performed and is presented. Testing procedures to detect linkage using the components of variance approach are discussed. The univariate and multivariate analyses showed effects of locus 15 on chromosome 5 only for Q1. This result was confirmed when using ascertainment correction.

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Assessing linkage on chromosome 5 using components of variance approach: Univariate versus multivariate

Abstract

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