Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment

Gregory A. Jicha, Ronald C. Petersen, David S. Knopman, Bradley F. Boeve, Glenn E. Smith, Yonas E. Geda, Kris A. Johnson, Ruth Cha, Michael W. DeLucia, Heiko Braak, Dennis W. Dickson, Joseph E. Parisi

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34 Scopus citations


A previous autopsy study of patients with amnestic-type mild cognitive impairment (MCI) suggested an overrepresentation of argyrophilic grain disease (AGD). We studied 34 patients who had diagnoses of amnestic MCI during progression to dementia and who came to autopsy. Neuropathologic evaluation included routine histochemical and immunohistochemical methods, including a 4-repeat tau-specific marker (ET3). AGD was found in association with a variety of neuropathologic diseases in 18 (53%) cases but was the primary pathologic finding in only one (3%) case. ET3 allowed the detection of AGD in 5 additional cases missed using standard techniques. Cases with AGD were significantly older than those without (mean, 94 vs 84 years; p < 0.004, rank sum test). No significant differences were found between groups for other demographic variables, association of AGD with neuropathologic findings of Alzheimer disease, Lewy body, or cerebrovascular disease, or global measures of cognitive function, although there was a nonsignificant trend towards worsening cognitive status in cases with AGD. AGD is a common pathologic finding in subjects who have been diagnosed with amnestic MCI.

Original languageEnglish (US)
Pages (from-to)602-609
Number of pages8
JournalJournal of Neuropathology and Experimental Neurology
Issue number6
StatePublished - Jun 2006


  • Argyrophilic grain disease
  • Dementia
  • Mild cognitive impairment
  • Tau

ASJC Scopus subject areas

  • General Medicine


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