Are trefoil factors oncogenic?

Jo K. Perry, Nagarajan Kannan, Prudence M. Grandison, Murray D. Mitchell, Peter E. Lobie

Research output: Contribution to journalReview articlepeer-review

77 Scopus citations


Trefoil factors (TFFs), in particular TFF1, are classical estrogen-regulated genes and have served as markers of estrogen gene regulation by various environmental estrogens. TFFs are also regulated by several other factors including growth hormone (hGH), insulin-like growth factor-1 (IGF-1), epidermal growth factor (EGF) and various oncogenic stimuli. TFFs are secreted proteins present in serum and possess the potential to act as growth factors promoting cell survival, anchorage-independent growth and motility. Recent compelling evidence has emerged from experimental and clinical studies to indicate a pivotal role of TFFs in oncogenic transformation, growth and metastatic extension of common human solid tumours. This review will summarize the current evidence for the involvement of TFFs in human cancer.

Original languageEnglish (US)
Pages (from-to)74-81
Number of pages8
JournalTrends in Endocrinology and Metabolism
Issue number2
StatePublished - Mar 2008

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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