Are trefoil factors oncogenic?

Jo K. Perry; Nagarajan Kannan; Prudence M. Grandison; Murray D. Mitchell; Peter E. Lobie

doi:10.1016/j.tem.2007.10.003

Are trefoil factors oncogenic?

Jo K. Perry, Nagarajan Kannan, Prudence M. Grandison, Murray D. Mitchell, Peter E. Lobie

Laboratory Medicine and Pathology

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Abstract

Trefoil factors (TFFs), in particular TFF1, are classical estrogen-regulated genes and have served as markers of estrogen gene regulation by various environmental estrogens. TFFs are also regulated by several other factors including growth hormone (hGH), insulin-like growth factor-1 (IGF-1), epidermal growth factor (EGF) and various oncogenic stimuli. TFFs are secreted proteins present in serum and possess the potential to act as growth factors promoting cell survival, anchorage-independent growth and motility. Recent compelling evidence has emerged from experimental and clinical studies to indicate a pivotal role of TFFs in oncogenic transformation, growth and metastatic extension of common human solid tumours. This review will summarize the current evidence for the involvement of TFFs in human cancer.

Original language	English (US)
Pages (from-to)	74-81
Number of pages	8
Journal	Trends in Endocrinology and Metabolism
Volume	19
Issue number	2
DOIs	https://doi.org/10.1016/j.tem.2007.10.003
State	Published - Mar 2008

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.tem.2007.10.003

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@article{ad1d214640994e44be4c90cb7d14ab18,

title = "Are trefoil factors oncogenic?",

abstract = "Trefoil factors (TFFs), in particular TFF1, are classical estrogen-regulated genes and have served as markers of estrogen gene regulation by various environmental estrogens. TFFs are also regulated by several other factors including growth hormone (hGH), insulin-like growth factor-1 (IGF-1), epidermal growth factor (EGF) and various oncogenic stimuli. TFFs are secreted proteins present in serum and possess the potential to act as growth factors promoting cell survival, anchorage-independent growth and motility. Recent compelling evidence has emerged from experimental and clinical studies to indicate a pivotal role of TFFs in oncogenic transformation, growth and metastatic extension of common human solid tumours. This review will summarize the current evidence for the involvement of TFFs in human cancer.",

author = "Perry, {Jo K.} and Nagarajan Kannan and Grandison, {Prudence M.} and Mitchell, {Murray D.} and Lobie, {Peter E.}",

note = "Funding Information: This work was supported by the Breast Cancer Research Trust of New Zealand and the Foundation of Research Science and Technology.",

year = "2008",

month = mar,

doi = "10.1016/j.tem.2007.10.003",

language = "English (US)",

volume = "19",

pages = "74--81",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",