Aqueous humor outflow: What do we know? Where will it lead us?

Michael P. Fautsch, Douglas H. Johnson, Ted S. Acott, Makoto Aihara, Sanjoy K. Bhattacharya, Terete Borrás, Carl B. Camras, Mortimer M. Civan, Abbot F. Clark, Craig E. Crosson, Jonathan G. Crowston, David Epstein, C. Ross Ethier, Thomas F. Freddo, Haiyan Gong, Pedro Gonzalez, Simon W. John, Mark Johnson, Paul L. Kaufman, Paul A. KnepperJames D. Lindsey, Elke Lütjen-Drecoll, Donna M. Peters, P. Vasantha Rao, Sayon Roy, Paul Russell, Daniel Stamer, Ernst R. Tamm, Carol B. Toris, Robert N. Weinreb, Beatrice Yue, Paul Bornstein, Peter F. Davies, Benjamin Geiger, Dontscho Kerjaschki, James Mitchell, Eveline Schneeberger, Alan Stitt, David C. Zawieja, Charles Bosworth, John Grunden, Elizabeth Kim, Casey Kopczynski, Achim Krauss, Noorjahan Panjwani, Christopher Paterson, Granesh Prasanna, Douglas Rhee, Andy Whitlock, Darrell WuDunn

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


Many questions remain in the study of the normal aqueous outflow pathway and understanding of what is altered in POAG. One of the goals of the conference was to identify future areas of study that will improve our understanding of aqueous humor outflow. These questions have been summarized in Table 1. Finally, suggestions were made that the role of ARVO in research could be expanded in developing a consensus on terminology and techniques. "Giant vacuoles" of Schlemm's canal endothelium are not truly intracytoplasmic vacuoles, and the term and concept was initially confusing to the outside scientists at the conference. An ARVO consensus committee could resolve such issues. Similarly, should a consensus be reached on standard culture conditions for trabecular or Schlemm's canal cells? At present the comparisons of results from different laboratories can be difficult because of differences in culture media, serum supplements, and other culture conditions.

Original languageEnglish (US)
Pages (from-to)4181-4187
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Issue number10
StatePublished - Oct 2006

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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