Approach to therapy

Phil A. Hart, Suresh T. Chari

Research output: Chapter in Book/Report/Conference proceedingChapter


Autoimmune pancreatitis is a distinct form of chronic pancreatitis that is characterized by a dramatic response to steroid treatment. In addition to resolution of the pancreatic manifestations, disease activity in other affected organs is also steroid responsive. The primary goal of treatment is reduction in acute inflammation and hopefully to prevent progression to irreversible fibrosis. Initial treatment also often requires management of diabetes mellitus and biliary obstruction. Though initial response to steroids is invariable, relapses are common. Nearly 50 % of patients relapse after initial therapy if no maintenance treatment is given, particularly those with involvement of the proximal biliary tract. Disease relapses generally occur in the pancreas or biliary tree; however, they can also develop in other previously unaffected organs. The remission rates using steroid treatment for disease relapses remain very high. There are several options for preventing relapses including long-term low-dose steroids, steroid-sparing immunomodulators, and rituximab; however, data supporting these strategies is just emerging.

Original languageEnglish (US)
Title of host publicationAutoimmune (IgG4-Related) Pancreatitis and Cholangitis
PublisherSpringer New York
Number of pages10
ISBN (Electronic)9781441964304
ISBN (Print)1441964290, 9781441964298
StatePublished - Feb 1 2013

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Approach to therapy'. Together they form a unique fingerprint.

Cite this