Apoptosis in cancer: Cause and cure

Research output: Contribution to journalReview articlepeer-review

168 Scopus citations


The accumulation of neoplastic cells can occur through enhanced proliferation, diminished cell turnover, or a combination of both processes. Although the potential contribution of diminished cell turnover to tumor development has been appreciated for a decade, more recent studies in animal models and clinical cancer specimens have elucidated the mechanisms by which alterations in the apoptotic machinery contribute to the process of carcinogenesis. At the same time, a different group of studies have demonstrated the feasibility of eliminating neoplastic cells by selectively inducing apoptosis. In this essay, we review recent developments in the fields of carcinogenesis and molecular therapeutics in light of new understanding of apoptotic pathways. (C) 2000 John Wiley and Sons, Inc.

Original languageEnglish (US)
Pages (from-to)1007-1017
Number of pages11
Issue number11
StatePublished - 2000

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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