Apolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease

Andrew B. Wolf, Jon Valla, Guojun Bu, Jungsu Kim, Mary Jo Ladu, Eric M. Reiman, Richard J. Caselli

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


APOE, which encodes apolipoprotein E, is the most prevalent and best established genetic risk factor for late-onset Alzheimer's disease. Current understanding of Alzheimer's disease pathophysiology posits an important role for apolipoprotein E in the disease cascade via its interplay with β-amyloid. However, evidence is also emerging for roles of apolipoprotein E in the disease process that are independent of β-amyloid. Particular areas of interest are lipid metabolism, tau pathology, neuroenergetics, neurodevelopment, synaptic plasticity, the neurovasculature, and neuroinflammation. The intent of this article is to review the literature in each of these areas.

Original languageEnglish (US)
Article number38
JournalAlzheimer's Research and Therapy
Issue number5
StatePublished - 2013

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience


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