Apolipoprotein e

Minerva M. Carrasquillo, Guojun Bu, Henrietta M. Nielsen

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


For the past two decades the epsilon 4 (ε4) allele of the Apolipoprotein E (APOE) gene has remained the only well established and greatest genetic risk factor for late-onset Alzheimer's disease (LOAD). ApoE is a 299-amino acid, 34.2 kDa, glycoprotein that has been implicated in multiple biological functions which will be described in this chapter. However, it is the evidence of its effect on β-amyloid metabolism that most strongly links this protein to the pathogenesis of LOAD.

Original languageEnglish (US)
Title of host publicationGenetic variants in Alzheimer's disease
PublisherSpringer New York
Number of pages17
ISBN (Electronic)9781461473091
ISBN (Print)146147308X, 9781461473084
StatePublished - Apr 1 2013

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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