Apolipoprotein e

Minerva M. Carrasquillo; Guojun Bu; Henrietta M. Nielsen

doi:10.1007/978-1-4614-7309-1_2

Apolipoprotein e

Minerva M. Carrasquillo, Guojun Bu, Henrietta M. Nielsen

Neuroscience

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

For the past two decades the epsilon 4 (ε4) allele of the Apolipoprotein E (APOE) gene has remained the only well established and greatest genetic risk factor for late-onset Alzheimer's disease (LOAD). ApoE is a 299-amino acid, 34.2 kDa, glycoprotein that has been implicated in multiple biological functions which will be described in this chapter. However, it is the evidence of its effect on β-amyloid metabolism that most strongly links this protein to the pathogenesis of LOAD.

Original language	English (US)
Title of host publication	Genetic variants in Alzheimer's disease
Publisher	Springer New York
Pages	7-23
Number of pages	17
ISBN (Electronic)	9781461473091
ISBN (Print)	146147308X, 9781461473084
DOIs	https://doi.org/10.1007/978-1-4614-7309-1_2
State	Published - Apr 1 2013

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-1-4614-7309-1_2

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AB - For the past two decades the epsilon 4 (ε4) allele of the Apolipoprotein E (APOE) gene has remained the only well established and greatest genetic risk factor for late-onset Alzheimer's disease (LOAD). ApoE is a 299-amino acid, 34.2 kDa, glycoprotein that has been implicated in multiple biological functions which will be described in this chapter. However, it is the evidence of its effect on β-amyloid metabolism that most strongly links this protein to the pathogenesis of LOAD.

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ER -

Apolipoprotein e

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