Anxiety, Depression, and Quality of Life after Procedural Intervention for Uterine Fibroids

Kedra Wallace, Elizabeth A. Stewart, Lauren A. Wise, Wanda Kay Nicholson, John Preston Parry, Shuaiqi Zhang, Shannon Laughlin-Tommaso, Vanessa Jacoby, Raymond M. Anchan, Michael P. Diamond, Sateria Venable, Amber Shiflett, Ganesa R. Wegienka, George Larry Maxwell, Daniel Wojdyla, Evan R. Myers, Erica Marsh

Research output: Contribution to journalArticlepeer-review


Background: Quality of life (QOL) and psychological health has been reported to be decreased among women with gynecological conditions such as uterine fibroids (UFs). Materials and Methods: Women enrolled in the Comparing Options for Management: PAtient-centered REsults for Uterine Fibroids (COMPARE-UF) registry, receiving procedural therapy for symptomatic UFs, were eligible for this analysis if they completed a series of health-related QOL surveys administered at three time points (baseline, 6-12 weeks postprocedure, and 1 year postprocedure; n = 1486). Ethical approval for this study was obtained at each recruiting site and the coordinating center (NCT02260752, Results: More than 26% (n = 393) of women reported moderate anxiety/depression on the baseline anxiety/depression domain of the Euro-QOL 5-dimension instrument. At both the 6-12 weeks and 1-year postprocedural follow-up, there was significant improvement in the UF QOL symptom severity score (p < 0.001, p < 0.001), the total UF symptom QOL score (p < 0.001, p < 0.001), and the Euro-QOL 5-dimension visual analog scale (p < 0.001, p = 0.004) compared with the preprocedural baseline scores. The reporting of anxiety/depression decreased by 66.4% among women who were at baseline, whereas 5.6% of women previously reporting no anxiety/depression reported anxiety/depression at the 1-year follow-up. Conclusion: UF symptoms were more severe among women reporting anxiety/depression at baseline. At the 1-year follow-up, health-related QOL scores improved among all women and the prevalence of anxiety/depression decreased in most, but not all women, whereas severity of anxiety/depression worsened in a small percentage of women (5.6%). Overall, these results suggest that UF treatment improves symptoms of anxiety/depression associated with symptomatic UFs.

Original languageEnglish (US)
Pages (from-to)415-424
Number of pages10
JournalJournal of Women's Health
Issue number3
StatePublished - Mar 2022


  • ablation
  • abnormal
  • bleeding
  • endometrial
  • hysterectomy
  • leiomyoma

ASJC Scopus subject areas

  • General Medicine


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