Anti-Neuronal Nuclear Antibody 3 Autoimmunity Targets Dachshund Homolog 1

Anastasia Zekeridou, Binxia Yang, Vanda A. Lennon, Yong Guo, Liang Wu, Claudia F. Lucchinetti, Andrew McKeon, Sean J. Pittock, Eoin P. Flanagan

Research output: Contribution to journalArticlepeer-review


The antigen specificity of Anti-Neuronal Nuclear Antibody-type 3 (ANNA3)-IgG is unknown. We identified Dachshund-homolog 1 (DACH1) as the ANNA3 autoantigen and confirmed it by antigen-specific assays, immunohistochemical colocalization and immune absorption experiments. Patients' median age was 63.5 years (range, 49–88); 67% were female. Neurological manifestations (information available for 30 patients) included one or more of neuropathy, 12; cognitive difficulties, 11; ataxia, 8; dysautonomia, 7. Evidence of a neoplasm was present in 27 of 30 (90%), most of neuroendocrine lineage. DACH1-IgG is rare and represents a novel proposed biomarker of neurological autoimmunity and cancer. ANN NEUROL 2022;91:670–675.

Original languageEnglish (US)
Pages (from-to)670-675
Number of pages6
JournalAnnals of neurology
Issue number5
StatePublished - May 2022

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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