Anterior chemotherapy in esophageal cancer

Suresh H. Advani, Tapan K. Saikia, Shanti Swaroop, Gopal Ramakrishnan, Chandrika N. Nair, Ketayun A. Dinshaw, Sanjay Sharma, Jitendra J. Vyas, Praful B. Desai

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Front loading chemotherapy using methotrexate (200 mg/m2) alone or methotrexate (200 mg/m2) with cisplatin (20 mg/m2 daily for 5 days) was used in epidermoid carcinoma of esophagus. Evaluation after two courses showed objective response of 50% or greater in 48% of patients with metbotrexate alone. Response rate was increased to 76.2% with addition of cisplatin to methotrexate. Small lesions (less than 10 cm) showed better response as compared to advanced cases. Therapy was generally well tolerated and good palliation was obtained even after the first course. Postchemotherapy treatment either with surgery or radiotherapy was tolerated without any major complications. The data confirm the short‐term usefulness of initial chemotherapy with methotrexate and cisplatin in esophageal cancer. Results of prolonged follow‐up will help to evaluate the role of front loading chemotherapy on long‐term survival. Cancer 56: 1502‐1506, 1985.

Original languageEnglish (US)
Pages (from-to)1502-1506
Number of pages5
Issue number7
StatePublished - Oct 1 1985

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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