Angiogenesis and current antiangiogenic strategies for the treatment of cancer

Rahmi Oklu, Thomas G. Walker, Stephan Wicky, Robin Hesketh

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Angiogenesis is a complex process critical for embryonic development and for survival. It is also a critical player in many pathologic processes, most notably in neoplasia. The cell signaling pathways involved in angiogenesis have become key targets for drug design, with more than 2,500 clinical trials currently under way. This review summarizes the essential features of angiogenesis and discusses therapeutic strategies that have been applied to specific diseases known to be associated with perturbation of normal angiogenic control.

Original languageEnglish (US)
Pages (from-to)1791-1805
Number of pages15
JournalJournal of Vascular and Interventional Radiology
Issue number12
StatePublished - Dec 2010


  • Abbreviations
  • BFGF
  • Basic fibroblast growth factor
  • DLL4
  • ERK
  • Extracellular signalregulated kinase
  • FDA
  • Food and Drug Administration
  • HIF
  • Hypoxia-inducible factor
  • MAPK
  • MMP
  • Matrix metalloproteinase
  • Mitogen-activated protein kinase
  • Notch ligand delta-like 4

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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