Angiocrine signaling in sinusoidal homeostasis and liver diseases

Jinhang Gao, Tian Lan, Enis Kostallari, Yangkun Guo, Enjiang Lai, Adrien Guillot, Bisen Ding, Frank Tacke, Chengwei Tang, Vijay H. Shah

Research output: Contribution to journalReview articlepeer-review

Abstract

The hepatic sinusoids are composed of liver sinusoidal endothelial cells (LSECs), which are surrounded by hepatic stellate cells (HSCs) and contain liver-resident macrophages called Kupffer cells, and other patrolling immune cells. All these cells communicate with each other and with hepatocytes to maintain sinusoidal homeostasis and a spectrum of hepatic functions under healthy conditions. Sinusoidal homeostasis is disrupted by metabolites, toxins, viruses, and other pathological factors, leading to liver injury, chronic liver diseases, and cirrhosis. Alterations in hepatic sinusoids are linked to fibrosis progression and portal hypertension. LSECs are crucial regulators of cellular crosstalk within their microenvironment via angiocrine signaling. This review discusses the mechanisms by which angiocrine signaling orchestrates sinusoidal homeostasis, as well as the development of liver diseases. Here, we summarise the crosstalk between LSECs, HSCs, hepatocytes, cholangiocytes, and immune cells in health and disease and comment on potential novel therapeutic methods for treating liver diseases.

Original languageEnglish (US)
Pages (from-to)543-561
Number of pages19
JournalJournal of hepatology
Volume81
Issue number3
DOIs
StatePublished - Sep 2024

Keywords

  • Kupffer cells
  • MASH
  • MASLD
  • NAFLD
  • NASH
  • alcoholic liver disease
  • hepatic stellate cells
  • liver fibrosis
  • liver regeneration
  • liver sinusoidal endothelial cells
  • metabolic dysfunction-associated steatotic liver disease
  • portal hypertension
  • sinusoidal capillarization

ASJC Scopus subject areas

  • Hepatology

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