Anatomic site-specific disparities in survival outcomes for penile squamous cell carcinoma

Mark D. Tyson, David A. Etzioni, Eric S. Wisenbaugh, Paul E. Andrews, Mitchell R. Humphreys, Robert G. Ferrigni, Scott K. Swanson, Erik P. Castle

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Objective: To identify the predictors of cancer-specific mortality of penile squamous cell carcinoma (PSCC) using a population-based database. Methods: Using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results registry, we performed a time-to-event analysis to determine which clinical parameters were useful in predicting cancer-specific mortality. Results: Our cohort consisted of 2515 cases of PSCC diagnosed from 1973 to 2007. The patients were divided into 2 groups: primary tumors of the prepuce (n = 722) and primary tumors of the glans, body, and overlapping lesions of the skin (n = 1793). The median follow-up for the cohort was 39 months (range 1-411). Compared with tumors of the prepuce, tumors of the body (hazard ratio 1.61, 95% confidence interval 1.00-2.60, P =.05) and overlapping tumors of the skin (hazard ratio 1.79, 95% confidence interval 1.13-2.83, P =.01) had a greater risk of cancer-specific mortality, even when controlling for age, Surveillance, Epidemiology, and End Results stage, and tumor grade. Furthermore, the disease-specific 10-year survival rate of those with preputial tumors was 89.4% compared with 78.7% for the other 3 groups combined (P <.0001). Conclusion: Anatomic site-specific disparities for PSCC survival appear to exist. Patients diagnosed with PSCC of the prepuce have greater overall long-term disease-specific survival than patients with primary tumors elsewhere.

Original languageEnglish (US)
Pages (from-to)804-808
Number of pages5
Issue number4
StatePublished - Apr 2012

ASJC Scopus subject areas

  • Urology


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