Analysis of failure after curative irradiation of extrahepatic bile duct carcinoma

S. J. Buskirk, L. L. Gunderson, S. E. Schild, C. E. Bender, H. J. Williams, D. C. McIlrath, J. S. Robinow, W. J. Tremaine, J. K. Martin

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


Thirty-four patients with subtotally resected or unresectable carcinoma of the extrahepatic bile ducts received radiation therapy; a minimum of 45 Gy (external beam) to the tumor and regional lymph nodes ± 5-fluorouracil (5- FU). Seventeen patients received an external beam boost of 5 to 15 Gy to the tumor, and a specialized boost was used in the remaining 17 patients (iridium-192 transcatheter seeds in 10 and intraoperative radiation therapy [IORT] with electrons in seven). The median time to death in all 34 patients was 12 months (range, 4 to 98 months). The only patients who survived longer than 18 months were those either with gross total or subtotal resection before external irradiation (2 of 6) or who received specialized boosts (192Ir, 3 of 10; IORT, 3 of 7). Local failure was documented in 9 of 17 patients who received external beam irradiation alone ± 5-FU, 3 of 10 patients who received an 192Ir boost, and 2 of 6 patients who received an IORT boost with curative intent.

Original languageEnglish (US)
Pages (from-to)125-131
Number of pages7
JournalAnnals of surgery
Issue number2
StatePublished - 1992

ASJC Scopus subject areas

  • Surgery


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