Analysis of elastography methods using mathematical and ex vivo data

Brett C. Byram, Michael R. Wahl, David Holmes, Amir Lerman, Richard A. Robb

Research output: Contribution to journalConference articlepeer-review


Intravascular ultrasound (IVUS) currently has a limited ability to characterize endovascular anatomic properties. IVUS elastography enhances the ability to characterize the biomechanical properties of arterial walls. A mathematical phantom generator was developed based on the characteristics of 30MHz, 64 element IVUS catheter images from excised canine femoral arteries. The difference between high and low-pressure intra-arterial images was modeled using phase shifts. The increase in phase shift occurred randomly, generally at every three pixels in our images. Using mathematical phantoms, different methods for calculating elastograms were quantitatively analyzed. Specifically, the effect of standard cross correlation versus cross correlation of the integral of the inflection characteristics for a given set of data, and the effect of an algorithm utilizing a non-constant kernel, were assessed. The specific methods found to be most accurate on the mathematical phantom data were then applied to ex vivo canine data of a scarred and a healthy artery. The algorithm detected significant differences between these two sets of arterial data. It will be necessary to obtain and analyze several more sets of canine arterial data in order to determine the accuracy and reproducibility of the algorithm.

Original languageEnglish (US)
Pages (from-to)1738-1747
Number of pages10
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5032 III
StatePublished - 2003
EventMedical Imaging 2003: Image Processing - San Diego, CA, United States
Duration: Feb 17 2003Feb 20 2003


  • Elastography
  • Image processing
  • Intra-vascular ultrasound imaging
  • Mathematical phantom

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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