An update on primary sclerosing cholangitis: From pathogenesis to treatment

M. H. Imam, J. A. Talwalkar, K. D. Lindor

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown etiology despite advances in medical research that have focused on uncovering its pathogenesis. Recent developments in the diagnosis of PSC including technological advances in magnetic resonanace cholangiography and the recognition of distinct clinical subtypes have led to more frequent early detection and appropriate therapy when indicated. Continued work in the areas of identifying genetic predisposing factors and novel molecular therapeutic targets are expected to create new opportunities for treating patients suffering from this chronic illness. In this review we highlight recent advances in PSC pathogenesis, diagnosis and management.

Original languageEnglish (US)
Pages (from-to)49-58
Number of pages10
JournalMinerva Gastroenterologica e Dietologica
Issue number1
StatePublished - Mar 1 2013


  • Liver
  • Magnetic resonance spectroscopy
  • Primary sclerosing cholangitis

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Gastroenterology


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