An update on biochemotherapy of advanced gastric and gastroesophageal adenocarcinoma

Peyman Haghighat, Tanios Bekaii-Saab

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Gastric and gastroesophageal adenocarcinoma (GGA) are significant worldwide health problems. With most patients presenting with advanced disease, palliative chemotherapy plays a significant role in treatment. Results from recent phase III studies of cytotoxic agents in combination therapy, such as docetaxel, oxaliplatin, irinotecan, capecitabine, and S-1, have been encouraging and provide patients with additional therapeutic options. Although these forthcoming regimens have allowed for more flexible patient-tailored therapy, survival continues to be suboptimal. Although still in its infancy, targeted blotherapy, including inhibitors of the vascular endothelial and epidermal growth factor receptors, seems to be promising and its incorporation into the next generation of clinical trials will hopefully improve outcomes and help advance future treatments. This article reviews current active chemotherapeutic regrimens and explores the role of novel targeted therapies in aclvanced GGA.

Original languageEnglish (US)
Pages (from-to)895-900
Number of pages6
JournalJNCCN Journal of the National Comprehensive Cancer Network
Issue number9
StatePublished - Oct 2008


  • Adenocarcinoma
  • Chemotherapy
  • Gastric
  • Gastroesophageal
  • Targeted therapy

ASJC Scopus subject areas

  • Oncology


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