Amenorrhea after lung cancer treatment

Elizabeth J. Cathcart-Rake, Kathryn J. Ruddy, Ruchi Gupta, Walter Kremers, Kelly Gast, H. Irene Su, Ann H. Partridge, Elizabeth A. Stewart, Han Liu, Yanqi He, Ping Yang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Objective:More than 5,000 premenopausal women are diagnosed with lung cancer annually in the United States. Limited data exist regarding the risk of treatment-related amenorrhea, a surrogate for infertility and early menopause, after systemic therapies for lung cancer.Methods:Premenopausal women diagnosed with lung cancer under age 50 were surveyed at diagnosis and annually thereafter about their menstrual status as a part of the Mayo Clinic Epidemiology and Genetics of Lung Cancer Research Program. Types of lung cancer-directed treatments were recorded, and frequencies of self-reported menopause at each survey were calculated.Results:A cohort of 182 premenopausal women were included in this study, with average age at lung cancer diagnosis 43 years (SD 6). Among the 85 patients who received chemotherapy, 64% self-reported that they had become menopausal within a year of diagnosis. Platinum salts were universally included in these chemotherapy regimens, and the majority of these women also received taxanes within 1 year of diagnosis. Only 15% of the 94 patients who did not receive systemic therapy within 1 year of diagnosis experienced self-reported menopause. Three patients received targeted therapy alone, two of whom remained premenopausal at the final qualifying survey, completed a median of 3 years after diagnosis.Conclusions:Chemotherapy for lung cancer patients appears to increase risk of early loss of menses in survivors.

Original languageEnglish (US)
Pages (from-to)306-310
Number of pages5
Issue number3
StatePublished - Mar 2019


  • Amenorrhea
  • Chemotherapy side effects
  • Menopause
  • Ovarian toxicity

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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