Allopurinol mouthwash for prevention of fluorouracil-induced stomatitis

W. Van der Vliet, C. Erlichman, T. Elhakim

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Clark and Slevin studied six patients with colorectal cancer who had fluorouracil-induced stomatitis. They observed a decrease in stomatitis in all six patients after treatment with allopurinol mouthwash 1 mg/mL. Two patients with taste abnormalities showed reductions in taste dysfunction. We undertook a similar study to determine whether allopurinol mouthwash can selectively protect the oral mucosa from toxicity. The results were compared with those for a historical control group.

Original languageEnglish (US)
Pages (from-to)655-658
Number of pages4
JournalClinical Pharmacy
Issue number9
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Pharmaceutical Science


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