Alleviation of cytotoxic therapy-induced normal tissue damage

C. L. Loprinzi, R. L. Foote, J. Michalak

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Cytotoxic chemotherapy and radiation therapy damage normal body tissues, resulting in stomatitis, conjunctivitis, esophagitis, proctitis, and dermatitis. Pursuant to this, the North Central Cancer Treatment Group has developed a series of clinical trials designed to study antidotes for these pathologic processes. These trials have demonstrated clinically helpful therapies (eg, oral cryotherapy for decreasing mucositis induced by 5- fluorouracil) and also have demonstrated lack of benefit for other proposed treatments. Results from several ongoing clinical trials should become available in the near future.

Original languageEnglish (US)
Pages (from-to)95-97
Number of pages3
JournalSeminars in oncology
Issue numberSUPPL. 3
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Hematology
  • Oncology


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