Airway Innervation and Plasticity in Asthma

L. E.M. Kistemaker, Y. S. Prakash

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Airway nerves represent a mechanistically and therapeutically important aspectthat requires better highlighting in the context of diseases such asasthma. Altered structure and function (plasticity) of afferent and efferentairway innervation can contribute to airway diseases. We describe establishedanatomy, current understanding of how plasticity occurs, and contributions ofplasticity to asthma, focusing on target-derived growth factors (neurotrophins).Perspectives toward novel treatment strategies and future research are provided.

Original languageEnglish (US)
Pages (from-to)283-298
Number of pages16
Issue number4
StatePublished - Jul 2019

ASJC Scopus subject areas

  • Physiology


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