Aging and respiratory viral infection: from acute morbidity to chronic sequelae

Yue Wu, Nick P. Goplen, Jie Sun

Research output: Contribution to journalReview articlepeer-review


The altered immune response in aged hosts play a vital role in contributing to their increased morbidity and mortality during respiratory virus infections. The aged hosts display impaired antiviral immune response as well as increased risk for long-term pulmonary sequelae post virus clearance. However, the underlying cellular and molecular mechanisms driving these alterations of the immune compartment have not been fully elucidated. During the era of COVID-19 pandemic, a better understanding of such aspects is urgently needed to provide insight that will benefit the geriatric patient care in prevention as well as treatment. Here, we review the current knowledge about the unique immune characteristics of aged hosts during homeostasis and respiratory virus infections.

Original languageEnglish (US)
Article number112
JournalCell and Bioscience
Issue number1
StatePublished - Dec 2021


  • Aging
  • COVID-19
  • Immune response
  • Influenza virus infection
  • Respiratory viral infections

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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