Aggressive multimodality treatment for locally advanced irresectable rectal cancer

R. Farouk, H. Nelson, L. L. Gunderson

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations


Background: Local failure rates are high for locally irresectable primary or recurrent colorectal cancer, even when chemoradiation therapy is employed. Aim: This review evaluates evidence supporting aggressive preoperative chemoradiation followed by maximal surgical resection and intraoperative radiation therapy to achieve disease control and cure for patients with locally advanced irresectable primary or recurrent rectal cancer. Results: A 5-year survival rate of 42 per cent with a central failure rate of 2 per cent may be achieved in patients with locally irresectable primary rectal cancer. In patients with locally recurrent disease, these values at 5 years are 18 and 28 per cent respectively. The 5-year incidence of distant metastasis remains high, affecting 64 per cent of patients with primary cancer and 75 per cent of those with recurrent cancer. Conclusion: A disease-free surgical resection margin remains paramount to achieve cure. Encouraging trends exist, however, for further evaluation of multimodality therapy as a means of reducing local recurrence of disease.

Original languageEnglish (US)
Pages (from-to)741-749
Number of pages9
JournalBritish Journal of Surgery
Issue number6
StatePublished - Jun 17 1997

ASJC Scopus subject areas

  • Surgery


Dive into the research topics of 'Aggressive multimodality treatment for locally advanced irresectable rectal cancer'. Together they form a unique fingerprint.

Cite this