Age, gender, and race/ethnic differences in total body and subregional bone density

A. C. Looker, L. J. Melton, T. Harris, L. Borrud, J. Shepherd, J. McGowan

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Total body bone density of adults from National Health and Nutrition Examination Survey (NHANES) 1999-2004 differed as expected for some groups (men>women and blacks>whites) but not others (whites>Mexican Americans). Cross-sectional age patterns in bone mineral density (BMD) of older adults differed at skeletal sites that varied by degree of weight-bearing. Introduction: Total body dual-energy X-ray absorptiometry (DXA) data offer the opportunity to compare bone density of demographic groups across the entire skeleton. Methods: The present study uses total body DXA data (Hologic QDR 4500A, Hologic, Bedford MA, USA) from the NHANES 1999-2004 to examine BMD of the total body and selected skeletal subregions in a wide age range of adult men and women from three race/ethnic groups. Total body, lumbar spine, pelvis, right leg, and left arm BMD and lean mass from 13,091 adults aged 20 years and older were used. The subregions were chosen to represent sites with different degrees of weight-bearing. Results: Mean BMD varied in expected ways for some demographic characteristics (men>women and non-Hispanic blacks>non- Hispanic whites) but not others (non-Hispanic whites>Mexican Americans). Differences in age patterns in BMD also emerged for some characteristics (sex) but not others (race/ethnicity). Differences in cross-sectional age patterns in BMD and lean mass by degree of weight-bearing in older adults were observed for the pelvis, leg, and arm. Conclusion: This information may be useful for generating hypotheses about age, race, and sex differences in fracture risk in the population.

Original languageEnglish (US)
Pages (from-to)1141-1149
Number of pages9
JournalOsteoporosis International
Issue number7
StatePublished - Jul 2009


  • Cross-sectional age patterns
  • Gender differences
  • Race/ethnic differences
  • Total body bone mineral density

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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