Age, gender, and percentage of circulating osteoprogenitor (COP) cells: The COP Study

Piumali Gunawardene, Ahmed Al Saedi, Lakshman Singh, Sandra Bermeo, Sara Vogrin, Steven Phu, Pushpa Suriyaarachchi, Robert J. Pignolo, Gustavo Duque

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Circulating osteoprogenitor (COP) cells are blood-borne cells which express a variety of osteoblastic markers and are able to form bone nodules in vivo. Whereas a high percentage of COP cells (%COP) is associated with vascular calcification, low %COP has been associated with disability and frailty. However, the reference range of %COP in age- and gender-matching populations, and the age-related changes in %COP remain unknown. A cross-sectional study was undertaken in 144 healthy volunteers in Western Sydney (20–90 year-old, 10 male and 10 female subjects per decade). %COP was quantified by flow cytometry. A high inter-and intra-rater reliability was found. In average, in this healthy population average of %COP was 0.42. There was no significant difference in %COP among the age groups. Similarly, no significant difference was found in %COP with gender, weight, height or BMI. In addition, we identified a normal reference range of %COP of 0.1–3.8%. In conclusion, in addition to the identification of steady levels of COP cells with age, we also identified a normal reference range of %COP, which could be used in future studies looking at musculoskeletal diseases in older populations.

Original languageEnglish (US)
Pages (from-to)68-72
Number of pages5
JournalExperimental Gerontology
StatePublished - Oct 1 2017


  • Circulating osteoprogenitors
  • Musculoskeletal
  • Osteosarcopenia
  • Stem cells

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology


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