Advances in Recapitulating Alzheimer’s Disease Phenotypes Using Human Induced Pluripotent Stem Cell-Based In Vitro Models

Md Fayad Hasan, Eugenia Trushina

Research output: Contribution to journalReview articlepeer-review

Abstract

Alzheimer’s disease (AD) is an incurable neurodegenerative disorder and the leading cause of death among older individuals. Available treatment strategies only temporarily mitigate symptoms without modifying disease progression. Recent studies revealed the multifaceted neurobiology of AD and shifted the target of drug development. Established animal models of AD are mostly tailored to yield a subset of disease phenotypes, which do not recapitulate the complexity of sporadic late-onset AD, the most common form of the disease. The use of human induced pluripotent stem cells (HiPSCs) offers unique opportunities to fill these gaps. Emerging technology allows the development of disease models that recapitulate a brain-like microenvironment using patient-derived cells. These models retain the individual’s unraveled genetic background, yielding clinically relevant disease phenotypes and enabling cost-effective, high-throughput studies for drug discovery. Here, we review the development of various HiPSC-based models to study AD mechanisms and their application in drug discovery.

Original languageEnglish (US)
Article number552
JournalBrain Sciences
Volume12
Issue number5
DOIs
StatePublished - May 2022

Keywords

  • 3D culture
  • Alzheimer’s disease
  • biofabrication
  • disease modeling
  • human induced pluripotent stem cell (HiPSC)
  • microfluidics
  • organoid
  • spheroid
  • stem cells

ASJC Scopus subject areas

  • General Neuroscience

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